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ea0092ps3-28-03 | Translational 2 | ETA2023

Molecular analysis of multiple foci of sporadic medullary thyroid carcinoma suggests that they are intrathyroidal metastases from the same primary tumor

Almeida Jacqueline , Ciampi Raffaele , Casalini Roberta , Ramone Teresa , Mori Sara , Cappagli Virginia , Materazzi Gabriele , Ugolini Clara , Basolo Fulvio , Ward Laura , Elisei Rossella , Romei Cristina

Sporadic medullary thyroid cancer (sMTC) presents mutations of the RET proto-oncogene in about 50% of the cases and of the RAS proto-oncogene in about 20% of the cases. In about 15% of cases, sMTC is multifocal and it is not known whether multiple foci can be considered as intrathyroidal metastases of the main tumor focus or if they can be considered as independent tumors. To clarify this issue, we examined the mutation profile of multiple intrathyroidal tumo...

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Endocrine Abstracts

Molecular analysis of multiple foci of sporadic medullary thyroid carcinoma suggests that they are intrathyroidal metastases from the same primary tumor

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